Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 6/20 | 0.42 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938423 | 0.82 | HSPA5 (0.54) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL1245772 | 0.80 | HSPA5 (0.52) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL4712987 | 0.80 | HSPA5 (0.52) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL29432666 | 0.80 | HSPA5 (0.52) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL10887755 | 0.78 | HSPA5 (0.50) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL11036278 | 0.78 | HSPA5 (0.50) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL10887766 | 0.78 | HSPA5 (0.50) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| Formaldehyde SCHEMBL28042523 | 0.77 | HSPA5 (0.48) | MGLLHSPA5AKR1B1TSHRCYP2D6 | |
| SCHEMBL7899861 | 0.74 | FAAH (0.50) | MGLLFAAHPRSS1PRSS2ELANE | |
| Sulfuric Acid SCHEMBL17027917 | 0.74 | HSPA5 (0.50) | MGLLHSPA5AKR1B1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767337-A | SELECTIVELY BREEDING TRANSGENIC MICE EXPRESSING DIFFERENT APOLIPOPROTEIN E ISOFORM | DUKE UNIVERSITY (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0842271-A1 | TRANSGENIC \"KNOCK OUT\" MICE EXPRESSING A HUMAN APOLIPOPROTEIN E | DUKE UNIVERSITY (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997005247-A1 | TRANSGENIC 'KNOCK OUT' MICE EXPRESSING A HUMAN APOLIPOPROTEIN E | DUKE UNIVERSITY (US) | 1997-02-13 | — | — | WO | disclosed |