SCHEMBL8675898

SCHEMBL8675898

CCCCCOC[C@@H]1O[C@H](n2cc(F)c(=O)[nH]c2=O)C(O)C1O

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 7/20 0.60
P2RY14 Q15391 5/20 0.60
NT5E P21589 1/20 0.60
TSHR P16473 1/20 0.57
LMNA P02545 1/20 0.57
MAPT P10636 1/20 0.57
PMP22 Q01453 1/20 0.57
HBB P68871 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
PLA2G1B P04054 1/20 0.49
ATG4B Q9Y4P1 1/20 0.49
DNPH1 O43598 1/20 0.48
PYGM P11217 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8675896 1.00 P2RY6 (0.60) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL11007076 0.99 P2RY6 (0.59) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL7600836 0.86 P2RY6 (0.66) P2RY6P2RY14NT5EPLA2G1BATG4B
SCHEMBL7996435 0.86 P2RY6 (0.66) P2RY6P2RY14NT5EPLA2G1BATG4B
SCHEMBL11578065 0.84 P2RY6 (0.56) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL11577162 0.84 P2RY6 (0.56) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL11578067 0.84 P2RY6 (0.56) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL10998262 0.84 P2RY6 (0.56) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL11577772 0.84 P2RY6 (0.56) P2RY6P2RY14NT5ETSHRLMNA
SCHEMBL11577775 0.84 P2RY6 (0.56) P2RY6P2RY14NT5ETSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0268678-B1 NOVEL 5-FLUOROURIDINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION FUJI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1992-07-29 EP claimed
EP-0268678-A1 NOVEL 5-FLUOROURIDINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION FUJI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-06-01 EP claimed
JP-63196519-A None JP disclosed
US-5783689-A Antibacterial and antifungal nucleosides UNIVERSITY OF NOTRE DAME (US) 1998-07-21 US disclosed
EP-0746336-A1 PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS IGEN, INC. (US) 1996-12-11 EP disclosed
EP-0746336-A4 PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS IGEN INC (US) 1996-07-26 EP disclosed
WO-1993002703-A1 PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS IGEN, INC. (US) 1993-02-18 WO disclosed
EP-0268678-B1 NOVEL 5-FLUOROURIDINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION FUJI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1992-07-29 EP disclosed
US-4892939-A ANTITUMOR, ANTIVIRAL AND IMMUNOSUPRESSIVE AGENTS FUJI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1990-01-09 US disclosed
JP-S63196519-A CARCINOSTATIC AGENT MITSUI TOATSU CHEM INC 1988-08-15 JP disclosed
EP-0268678-A1 NOVEL 5-FLUOROURIDINE COMPOUNDS AND PROCESS FOR THEIR PREPARATION FUJI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-06-01 EP disclosed
WO-1988003146-A1 NOVEL 5'-O-ACYL-5-FLUOROURIDINES AND PROCESS FOR THEIR PREPARATION FUJI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-05-05 WO disclosed