Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 14/20 | 0.55 |
| ▸ | RARB | P10826 | 14/20 | 0.55 |
| ▸ | RARG | P13631 | 13/20 | 0.55 |
| ▸ | RXRA | P19793 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645615 | 0.83 | RARB (0.39) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL5846305 | 0.74 | RARG (0.80) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL18775432 | 0.74 | RARB (0.73) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL5847754 | 0.73 | RARB (0.72) | RARARARBRARGRXRAABCB1 | |
| SCHEMBL8457129 | 0.73 | CYP3A4 (0.57) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL17327788 | 0.73 | RARA (0.67) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL5846360 | 0.72 | RARB (0.65) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9188355 | 0.72 | CYP3A4 (0.56) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9183745 | 0.72 | RARB (0.74) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9186798 | 0.72 | CYP3A4 (0.56) | RARARARBRARGRXRACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728739-A | LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-03-17 | — | — | US | disclosed |