Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.63 |
| ▸ | WNT3A | P56704 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA6 | P23280 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | TPMT | P51580 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18652086 | 0.89 | MAPK1 (0.63) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL141068 | 0.86 | HTT (0.49) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2848243 | 0.86 | HTT (0.67) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10830384 | 0.86 | PDE4B (0.57) | TSHRMAPTCTNNB1WNT3AALDH1A1 | |
| SCHEMBL1659363 | 0.85 | MAPT (0.71) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10455919 | 0.85 | CTNNB1 (0.83) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6719741 | 0.84 | PDE4D (0.50) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3893527 | 0.83 | TSHR (0.66) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29578705 | 0.83 | MEN1 (0.73) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL515746 | 0.83 | MEN1 (0.73) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114873-B1 | N-[3-BROMO-4-(3- [18F]FLUOROPROPOXY)-BENZYL]-GUANIDINE FOR IMAGING CARDIAC INNERVATION | LANTHEUS MEDICAL IMAGING INC (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-2474526-A2 | Ligands for imaging cardiac innervation | Lantheus Medical Imaging, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2474525-A2 | Ligands for imaging cardiac innervation | Lantheus Medical Imaging, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2474523-A2 | Ligands for imaging cardiac innervation | Lantheus Medical Imaging, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2474524-A2 | Ligands for imaging cardiac innervation | Lantheus Medical Imaging, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2008083056-A2 | LIGANDS FOR IMAGING CARDIAC INNERVATION | LANTHEUS MEDICAL IMAGING, INC. (US) | 2008-07-10 | — | — | WO | disclosed |
| WO-1998024740-A1 | FLUORINATION OF CARBONYL-SUBSTITUTED AROMATIC COMPOUNDS | F2 CHEMICALS LIMITED (GB) | 1998-06-11 | — | — | WO | disclosed |