SCHEMBL8683146

SCHEMBL8683146

CCOC(=O)COP(=O)(OCC)OCC

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.56
GAA P10253 2/20 0.46
MGAM O43451 1/20 0.46
SI P14410 1/20 0.46
MGAM2 Q2M2H8 1/20 0.46
ALDH1A1 P00352 5/20 0.43
TRPA1 O75762 1/20 0.43
CYP1A2 P05177 1/20 0.38
LMNA P02545 1/20 0.37
HSD17B10 Q99714 1/20 0.37
ALOX15 P16050 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CYP3A4 P08684 1/20 0.36
TP53 P04637 1/20 0.36
SOAT1 P35610 1/20 0.36
PPARD Q03181 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10012851 0.83 TSHR (0.56) TSHRGAAMGAMSIMGAM2
SCHEMBL10012496 0.81 TSHR (0.45) TSHR
SCHEMBL10011624 0.81 TDP1 (0.45) TSHRGAAALDH1A1HSD17B10TDP1
SCHEMBL5944704 0.80 MGAM (0.48) TSHRGAAMGAMSIMGAM2
SCHEMBL11039746 0.80 GAA (0.48) TSHRGAAMGAMSIMGAM2
SCHEMBL5481711 0.79 TSHR (0.60) TSHRGAAMGAMSIMGAM2
SCHEMBL19512090 0.78 GAA (0.46) TSHRGAAMGAMSIMGAM2
SCHEMBL10012576 0.78 TSHR (0.50) TSHRTDP1CYP3A4TP53PPARD
SCHEMBL27771235 0.77 TSHR (0.62) TSHRALDH1A1LMNAHSD17B10TDP1
SCHEMBL13537806 0.77 GAA (0.44) TSHRGAAMGAMSIMGAM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101602705-A Hexahydroisoindole-1-keto compound and synthetic method thereof UNIV ZHEJIANG (CN) 2009-12-16 CN disclosed
US-5731455-A ALKYL 2-ALKYLACYLACRYLATE CHEMICAL INTERMEDIATE; ANTICHOLESTEROL AGENTS SHIONOGI & CO., LTD. (JP) 1998-03-24 US disclosed
EP-0597107-B1 LIGNAN ANALOG, PRODUCTION THEREOF, AND HYPOLIPIDEMIC DRUG SHIONOGI & CO (JP) 1996-07-03 EP disclosed
US-5502216-A ANTICHOLESTEROL SHIONOGI & CO., LTD. (JP) 1996-03-26 US disclosed
EP-0701991-A1 Process for the preparation of lignin analogues and starting materials therefor SHIONOGI & CO., LTD. (JP) 1996-03-20 EP disclosed
US-5449814-A Dehydration; Michael condensation SHIONOGI & CO., LTD. (JP) 1995-09-12 US disclosed
US-5420333-A Hydroxy ketone compounds SHIONOGI & CO., LTD. (JP) 1995-05-30 US disclosed
EP-0597107-A1 LIGNAN ANALOG, PRODUCTION THEREOF, AND HYPOLIPIDEMIC DRUG SHIONOGI & CO., LTD. (JP) 1994-05-18 EP disclosed
US-4883916-A ANTICHOLESTEROL, ANTIARTERIOSCELEROSIS EISAI CO., LTD. (JP) 1989-11-28 US disclosed
EP-0047119-B1 CARBOXAMIDE COMPOUNDS AS SRS-A ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THE PREPARATION, AND INTERMEDIATES USEFUL THEREIN PFIZER INC. (US) 1984-05-09 EP disclosed