Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959983 | 0.73 | ACSS2 (0.33) | MAPK1 | |
| SCHEMBL8682497 | 0.72 | KDM4E (0.39) | MAPK1MAPK3 | |
| SCHEMBL14271520 | 0.69 | SLC22A12 (0.36) | — | |
| SCHEMBL6752447 | 0.69 | MAP2K4 (0.42) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL31581036 | 0.63 | MAPK1 (0.47) | MAPK1MAP2K4MAPKAPK3MAPK6MAPK3 | |
| SCHEMBL1758985 | 0.63 | MAP2K4 (0.47) | MAPK1MAP2K4MAPKAPK3MAPK6JAK2 | |
| SCHEMBL4388255 | 0.62 | S1PR1 (0.40) | — | |
| SCHEMBL4960504 | 0.62 | ACSS2 (0.38) | — | |
| SCHEMBL2866791 | 0.62 | MAP2K4 (0.69) | MAPK1MAP2K4MAPKAPK3MAPK6MAPK3 | |
| SCHEMBL2861172 | 0.62 | LRRK2 (0.61) | MAPK1MAP2K4MAPKAPK3MAPK6MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |