Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.65 |
| ▸ | FLT1 | P17948 | 5/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.65 |
| ▸ | RET | P07949 | 9/20 | 0.64 |
| ▸ | KIF5B | P33176 | 8/20 | 0.64 |
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.62 |
| ▸ | FLT4 | P35916 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 5/20 | 0.60 |
| ▸ | BRAF | P15056 | 5/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055589 | 0.88 | RAF1 (0.76) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL156289 | 0.88 | KDR (0.83) | KDRFLT1FGFR1RETKIF5B | |
| Hydrochloric Acid SCHEMBL28007000 | 0.87 | KDR (0.81) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL1467058 | 0.87 | KDR (0.83) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL8684 | 0.84 | KDR (0.82) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL5241456 | 0.83 | KDR (0.83) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL7215803 | 0.82 | KDR (0.89) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL18158611 | 0.81 | KDR (0.82) | KDRFLT1FGFR1RETKIF5B | |
| Trifluoroacetic Acid SCHEMBL2089050 | 0.81 | KDR (0.70) | KDRFLT1FGFR1RETKIF5B | |
| Trifluoroacetic Acid SCHEMBL29372105 | 0.81 | KDR (0.70) | KDRFLT1FGFR1RETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943240-B1 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2009-11-11 | — | — | EP | disclosed |