Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | SNCA | P37840 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 9/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685678 | 0.91 | KDM4C (0.42) | ALDH1A1HTTAPPSNCACSNK2A2 | |
| SCHEMBL8685069 | 0.89 | APP (0.51) | ALDH1A1HTTAPPSNCABACE1 | |
| SCHEMBL8685637 | 0.87 | HPGD (0.53) | HPGD | |
| SCHEMBL8685641 | 0.87 | HPGD (0.53) | HPGD | |
| SCHEMBL8690608 | 0.80 | NPC1 (0.54) | ALDH1A1HTTAPPSNCABACE1 | |
| SCHEMBL8685673 | 0.78 | HPGD (0.53) | HPGD | |
| SCHEMBL8685670 | 0.78 | HPGD (0.53) | HPGD | |
| SCHEMBL8685618 | 0.78 | PARP1 (0.42) | ALDH1A1HTTAPPSNCAHPGD | |
| SCHEMBL8685570 | 0.77 | CYP2A6 (0.53) | NOS1APPSNCABACE1BRD4 | |
| SCHEMBL8685065 | 0.76 | PIM1 (0.53) | APPSNCABACE1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |