Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937012 | 0.86 | SMN1; SMN2 (0.46) | CYP1A2S1PR1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL8686025 | 0.85 | SMN1; SMN2 (0.53) | CYP1A2S1PR1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL8687119 | 0.81 | S1PR1 (0.44) | S1PR1PPARGPPARAMAPT | |
| SCHEMBL8686060 | 0.75 | GABRA1 (0.46) | SMN1; SMN2LMNARAB9AMAPTTDP1 | |
| SCHEMBL8685915 | 0.73 | PARP10 (0.49) | POLBNPC1ALDH1A1 | |
| SCHEMBL8686093 | 0.72 | PPARG (0.47) | L3MBTL1LMNAPPARGPPARAMAPT | |
| SCHEMBL6815200 | 0.71 | CYP1A2 (0.51) | CYP1A2L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL8306282 | 0.71 | CA9 (0.51) | CYP1A2CASP3SENP8SENP7SENP6 | |
| SCHEMBL12603677 | 0.71 | CYP1A2 (0.51) | CYP1A2L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL16440164 | 0.71 | CYP1A2 (0.51) | CYP1A2L3MBTL1CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780490-A | A O-(2,4-OXA(OR THIA)ZOLIDINYL)PHENYLOXY(OR THIO OR AMINO) ALKYLOXIME; ALDOSE REDUCTASE INHIBITORS; ANTIDIABETIC AND -HYPOGLYCEMIC AGENTS; LIVER, SKIN AND UROGENITAL DISORDERS | SANKYO COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| US-5703096-A | ANTIDIABETIC AGENTS; ALDOSE REDUCTASE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |