Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265845 | 0.75 | PARP1 (0.42) | PARP1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2749356 | 0.69 | APOBEC3A (0.46) | PTGS1MEN1KMT2AALDH1A1ADORA2A | |
| SCHEMBL8684135 | 0.69 | PARP1 (0.45) | PARP1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8684094 | 0.68 | SMN1; SMN2 (0.42) | PARP1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL23998612 | 0.68 | PTGS1 (0.44) | PTGS1MEN1KMT2AALDH1A1ADORA2A | |
| SCHEMBL23998402 | 0.67 | PTGS1 (0.50) | PTGS1ALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL23998453 | 0.67 | PTGS1 (0.44) | PTGS1MEN1KMT2AADORA2AADORA2B | |
| SCHEMBL8684341 | 0.66 | IDO1 (0.48) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL8684139 | 0.65 | RAD51 (0.39) | PTGS2 | |
| SCHEMBL23998389 | 0.64 | KDM4E (0.49) | PTGS1MEN1KMT2AALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723481-A | ANTIULCER AGENTS AND 5-LIPOXYGENASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| US-5698576-A | POSSESS ANTI-ULCER AND 5-LIPOXYGENASE INHIBITORY ACTIVITIES | SANKYO COMPANY, LIMITED (JP) | 1997-12-16 | — | — | US | disclosed |
| US-5665752-A | LIPOXYGENASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1997-09-09 | — | — | US | disclosed |
| US-5354768-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-11 | — | — | US | disclosed |
| EP-0353047-B1 | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1994-10-05 | — | — | EP | disclosed |
| US-5232939-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO COMPANY LIMITED (JP) | 1993-08-03 | — | — | US | disclosed |
| EP-0353047-A2 | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |