SCHEMBL8686281

SCHEMBL8686281

O=c1[nH]nnn1-c1cc(Cl)nc(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
RECQL P46063 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5906130 0.85 NPSR1 (0.35)
SCHEMBL8691281 0.80 CYP17A1 (0.34) RECQL
SCHEMBL14347496 0.77 TP53 (0.39) ALDH1A1
SCHEMBL8599564 0.76 HSP90AA1 (0.39) ALDH1A1LMNA
SCHEMBL5905977 0.76 GAA (0.42) LMNA
SCHEMBL5906345 0.75 GAA (0.47) KDM4EALDH1A1LMNA
SCHEMBL3239509 0.75 IDO1 (0.46) KDM4EALDH1A1
SCHEMBL8304443 0.74 DAO (0.31)
SCHEMBL8686267 0.74 IDO1 (0.46)
SCHEMBL8686907 0.74 KDM4E (0.35) KDM4EALDH1A1LMNARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1047777-C Pyridyl tetrazolinone derivatives, and preparation method, composition and application thereof BAYER AGROCHEM KK (JP) 1999-12-29 CN disclosed
CN-1224014-A Pyridyltetrazolinone derivatives BAYER AGROCHEM KK (JP) 1999-07-28 CN disclosed
US-5710278-A Herbicidal 1-pyridyltetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1998-01-20 US disclosed
US-5641727-A Herbicidal 1-pyridyltetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1997-06-24 US disclosed
CN-1121918-A 1-pyridyltetrazolinone derivatives BAYER AGROCHEM KK (JP) 1996-05-08 CN disclosed
EP-0692482-A2 1-pyridyltetrazolinone derivatives NIHON BAYER AGROCHEM K.K. (JP) 1996-01-17 EP disclosed