SCHEMBL8686287

SCHEMBL8686287

Cc1ccc(C)c2c1C(C(=O)Oc1c(F)ccc(F)c1F)c1ccccc1N2C

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 1/20 0.38
HDAC4 P56524 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.34
GAA P10253 2/20 0.34
LMNA P02545 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
EGFR P00533 1/20 0.33
SRC P12931 1/20 0.33
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7588820 0.88 HDAC4 (0.40) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL29382936 0.85 HDAC4 (0.48) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL3859311 0.85 HDAC4 (0.48) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL8688713 0.83 KMT2A (0.36) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL8688894 0.81 MEN1 (0.35) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL7591257 0.80 HDAC4 (0.40) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL3858839 0.78 TAS1R3 (0.34) MEN1KMT2AMAPTGAALMNA
SCHEMBL14153964 0.78 SLC6A2 (0.33) MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8686432 0.76 KMT2A (0.35) MEN1KMT2AMAPTHDAC4HDAC7
SCHEMBL914119 0.75 HDAC4 (0.39) MEN1KMT2AMAPTHDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5723295-A MULTISTAGE CHEMILUMINESCENT ASSAY WITH PEROXIDASE ENZYME, PH ADJUSTMENT LUMIGEN, INC. (US) 1998-03-03 US claimed
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 US claimed
US-5723295-A MULTISTAGE CHEMILUMINESCENT ASSAY WITH PEROXIDASE ENZYME, PH ADJUSTMENT LUMIGEN, INC. (US) 1998-03-03 US disclosed
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 US disclosed