Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | NAT1 | P18440 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811044 | 1.00 | PARP1 (0.53) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8811049 | 0.87 | PARP1 (0.39) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8810698 | 0.83 | PARP1 (0.53) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8810694 | 0.83 | PARP1 (0.53) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8686566 | 0.83 | PARP1 (0.52) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8686570 | 0.83 | PARP1 (0.52) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8811137 | 0.82 | PARP1 (0.51) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8811144 | 0.82 | PARP1 (0.51) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8690614 | 0.82 | PARP1 (0.76) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8685868 | 0.82 | PARP1 (0.53) | PARP1TTRMEN1AKR1B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |