Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811044 | 0.87 | PARP1 (0.53) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8686335 | 0.87 | PARP1 (0.53) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8686578 | 0.83 | PARP1 (0.39) | PARP1MEN1KMT2AALDH1A1TTR | |
| SCHEMBL8810705 | 0.82 | PARP1 (0.41) | PARP1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8811154 | 0.82 | PARP1 (0.38) | PARP1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8685872 | 0.82 | PARP1 (0.39) | PARP1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8811097 | 0.82 | PARP1 (0.58) | PARP1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8810967 | 0.80 | PARP1 (0.38) | PARP1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL8685967 | 0.80 | PARP1 (0.50) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8685568 | 0.79 | KMT2A (0.45) | PARP1CSNK2A2CLK1CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |