Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | NAT1 | P18440 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811988 | 1.00 | PARP1 (0.60) | PARP1KMT2ALMNAHPGDIGF1R | |
| SCHEMBL8813667 | 0.89 | PARP1 (0.61) | PARP1KMT2ALMNAIGF1RTTR | |
| SCHEMBL8690587 | 0.89 | PARP1 (0.61) | PARP1KMT2ALMNAIGF1RTTR | |
| SCHEMBL8687701 | 0.89 | PARP1 (0.76) | PARP1KMT2AHPGDIGF1RTTR | |
| SCHEMBL8811679 | 0.89 | PARP1 (0.76) | PARP1KMT2AHPGDIGF1RTTR | |
| SCHEMBL8811994 | 0.88 | PARP1 (0.46) | PARP1KMT2ALMNAHPGDMEN1 | |
| SCHEMBL8685837 | 0.88 | PARP1 (0.62) | PARP1KMT2AIGF1RTTRMEN1 | |
| SCHEMBL8811177 | 0.88 | PARP1 (0.62) | PARP1KMT2AIGF1RTTRMEN1 | |
| SCHEMBL8686629 | 0.88 | PARP1 (0.64) | PARP1KMT2ALMNAHPGDIGF1R | |
| SCHEMBL8813928 | 0.88 | PARP1 (0.64) | PARP1KMT2ALMNAHPGDIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |