Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | NPM1 | P06748 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810605 | 1.00 | PARP1 (0.58) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8690518 | 0.90 | PARP1 (0.57) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8810593 | 0.90 | PARP1 (0.57) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8685564 | 0.89 | PARP1 (0.74) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8810613 | 0.89 | PARP1 (0.44) | PARP1APPNPM1SNCA | |
| SCHEMBL8811256 | 0.89 | PARP1 (0.74) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8809167 | 0.86 | PARP1 (0.62) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8685371 | 0.86 | PARP1 (0.62) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8685959 | 0.86 | PARP1 (0.66) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8685962 | 0.86 | PARP1 (0.66) | PARP1MEN1KMT2ATTRAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |