⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6639420 | 0.79 | — | — | |
| SCHEMBL10510061 | 0.77 | — | — | |
| SCHEMBL10434775 | 0.76 | — | — | |
| SCHEMBL1323848 | 0.71 | — | — | |
| SCHEMBL10434774 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL11592382 | 0.70 | NPSR1 (0.53) | — | |
| SCHEMBL134244 | 0.70 | — | — | |
| SCHEMBL13484119 | 0.70 | — | — | |
| SCHEMBL4180852 | 0.70 | FAAH (0.54) | — | |
| SCHEMBL11622680 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5795899-A | Soluble salts of 4-amino-2-(4,4-dimethylimidazolidin-2-on-1-yl) pyrimidine-5-carboxylic acid N-methyl-N-(3-trifluoromethylphenyl)-amide, a process for the preparation thereof, the use thereof as pharmaceuticals and starting materials | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-18 | — | — | US | disclosed |
| EP-0557877-B1 | Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products | HOECHST AG (DE) | 1997-09-24 | — | — | EP | disclosed |
| EP-0557879-B1 | 4-amino-2-ureido-5-pyrimidincarboxamide, process for their preparation, medicines containing those compounds and their use | HOECHST AG (DE) | 1997-01-08 | — | — | EP | disclosed |
| US-5571816-A | TREATMENT OF LIPID METABOLISM DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0557879-A1 | 4-amino-2-ureido-5-pyrimidincarboxamide, process for their preparation, medicines containing those compounds and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-01 | — | — | EP | disclosed |
| EP-0557877-A1 | Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-01 | — | — | EP | disclosed |
| EP-0012361-B1 | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4285946-A | ANOREXIGENIC AGENTS; TREATING DISTURBANCES OF THE METABOLISM OF LIPIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-08-25 | — | — | US | disclosed |
| EP-0012361-A1 | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-06-25 | — | — | EP | disclosed |