Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PROC | P04070 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732522 | 0.92 | PTGS2 (0.56) | PTGS2PTGS1PDPK1F2F10 | |
| SCHEMBL8733795 | 0.91 | PTGS2 (0.48) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8691417 | 0.91 | PTGS2 (0.70) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8692115 | 0.90 | PTGS2 (0.49) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8689252 | 0.87 | PTGS2 (0.55) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8688939 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8693453 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1PDPK1 | |
| SCHEMBL6341483 | 0.84 | PTGS2 (0.81) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8693370 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8730016 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |