Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | BRS3 | P32247 | 2/20 | 0.57 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.57 |
| ▸ | GABRP | O00591 | 1/20 | 0.56 |
| ▸ | GABRD | O14764 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689585 | 1.00 | HDAC8 (0.63) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL30736497 | 0.90 | MAPT (0.69) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL901463 | 0.90 | MAPT (0.69) | HDAC8MEN1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL9834221 | 0.89 | MAPT (0.67) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8689768 | 0.88 | MAPT (0.63) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL10691172 | 0.88 | MAPT (0.60) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8689774 | 0.88 | MAPT (0.63) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7613225 | 0.88 | KMT2A (0.60) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8690029 | 0.88 | HDAC8 (0.60) | HDAC8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8690022 | 0.88 | HDAC8 (0.60) | HDAC8MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792760-A | USEFUL IN TREATMENT OF PSYCHOLOGICAL AND CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1997038692-A1 | BISINDOLES FOR TREATING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1997-10-23 | — | — | WO | disclosed |