Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | UBE2N | P61088 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693305 | 0.79 | MAPT (0.41) | HDAC3HDAC1HDAC2NCOR2KMT2A | |
| SCHEMBL8690278 | 0.76 | HDAC3 (0.38) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL8382040 | 0.70 | EPHX2 (0.38) | HDAC3HDAC1HDAC2KMT2AMEN1 | |
| SCHEMBL8879400 | 0.69 | LMNA (0.36) | ALDH1A1HTTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL8381422 | 0.69 | EPHX2 (0.37) | HDAC3HDAC1HDAC2KMT2AMEN1 | |
| SCHEMBL7988309 | 0.68 | CA12 (0.44) | KMT2AMEN1HTTGAASMN1; SMN2 | |
| SCHEMBL7988305 | 0.68 | CA12 (0.44) | KMT2AMEN1HTTGAASMN1; SMN2 | |
| SCHEMBL7987377 | 0.67 | MAPT (0.42) | HDAC3HDAC1HDAC2NCOR2KMT2A | |
| SCHEMBL7987374 | 0.67 | MAPT (0.42) | HDAC3HDAC1HDAC2NCOR2KMT2A | |
| SCHEMBL6646490 | 0.65 | LMNA (0.33) | KMT2AMEN1CYP2C19SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747522-A | ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS; ANTITUMOR AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5670515-A | TREATMENT OF THROMBOSIS, STROKE, CARDIAC INFARCT, INFLAMMATION, AND ARTERIOSCLEROSIS; ANTITUMOR AGENTS, WOUND HEALING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-23 | — | — | US | disclosed |