SCHEMBL8690289

SCHEMBL8690289

C=C(Cl)CNc1c(C(=O)CC)c(=O)[nH]c2c(C(F)(F)F)cc(Cl)cc12

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CAPN1 P07384 1/20 0.32
CSF1R P07333 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8690738 0.85 CAPN1 (0.34) CAPN1
SCHEMBL7813747 0.80 CAPN1 (0.41) CAPN1CSF1R
SCHEMBL8693278 0.76 ALOX15 (0.33) CAPN1CSF1R
SCHEMBL8689581 0.74 CAPN1 (0.41) CAPN1
SCHEMBL8695097 0.73 MEN1 (0.38) CAPN1
SCHEMBL8693274 0.73 ALOX15 (0.31) CAPN1CSF1R
SCHEMBL8692858 0.73 CAPN1 (0.38) CAPN1
SCHEMBL8690699 0.72 CAPN1 (0.35) CAPN1
SCHEMBL8692993 0.71 CAPN1 (0.36) CAPN1
SCHEMBL8696568 0.71 CAPN1 (0.31) CAPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5707931-A 4-amino-2-quinolinone derivatives KOREA RESEARCH INTSITUTED OF CHEMICAL TECHNOLOGY (KR) 1998-01-13 US disclosed
EP-0707569-A1 4-AMINO-2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1996-04-24 EP disclosed
WO-1995000488-A1 4-AMINO-2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-01-05 WO disclosed