Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888660 | 0.82 | PDE4A (0.51) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8688573 | 0.80 | PDE4A (0.50) | PDE4APDE4BPDE4DPDE4CMEN1 | |
| SCHEMBL7390717 | 0.80 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8692223 | 0.79 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1388242 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL1388244 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8481926 | 0.78 | PDE4B (0.55) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7391724 | 0.77 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE4CKMT2A | |
| SCHEMBL7317214 | 0.77 | CYP19A1 (0.51) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5190936 | 0.76 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5786354-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-28 | — | — | US | claimed |
| US-5786354-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-28 | — | — | US | disclosed |