Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.59 |
| ▸ | TTR | P02766 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | NAT1 | P18440 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809818 | 1.00 | PARP1 (0.59) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8813508 | 0.88 | PARP1 (0.59) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8690423 | 0.88 | PARP1 (0.59) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8809827 | 0.88 | PARP1 (0.45) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8685246 | 0.86 | PARP1 (0.57) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8813612 | 0.86 | PARP1 (0.57) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8687046 | 0.85 | PARP1 (0.56) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8685487 | 0.85 | PARP1 (0.56) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8810443 | 0.85 | PARP1 (0.56) | PARP1TTRMEN1KMT2AAKR1B1 | |
| SCHEMBL8810447 | 0.85 | PARP1 (0.56) | PARP1TTRMEN1KMT2AAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |