Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.57 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 4/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.48 |
| ▸ | STK17B | O94768 | 2/20 | 0.48 |
| ▸ | BCL2 | P10415 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.48 |
| ▸ | CAMK4 | Q16566 | 2/20 | 0.48 |
| ▸ | MAPK15 | Q8TD08 | 2/20 | 0.48 |
| ▸ | PNPLA2 | Q96AD5 | 2/20 | 0.48 |
| ▸ | HIPK3 | Q9H422 | 2/20 | 0.48 |
| ▸ | NAT1 | P18440 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813612 | 1.00 | PARP1 (0.57) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8813618 | 0.88 | PARP1 (0.43) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8690423 | 0.86 | PARP1 (0.59) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8813508 | 0.86 | PARP1 (0.59) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8690901 | 0.86 | PARP1 (0.59) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8809818 | 0.86 | PARP1 (0.59) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8685962 | 0.85 | PARP1 (0.66) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8685959 | 0.85 | PARP1 (0.66) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8810443 | 0.83 | PARP1 (0.56) | PARP1TTRMEN1AKR1B1KMT2A | |
| SCHEMBL8685487 | 0.83 | PARP1 (0.56) | PARP1TTRMEN1AKR1B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |