Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869493 | 0.91 | EIF2AK3 (0.47) | EIF2AK3MAPK1S1PR1PIK3CDCYP3A4 | |
| SCHEMBL869247 | 0.82 | EIF2AK3 (0.39) | EIF2AK3MAPK1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL868753 | 0.78 | EIF2AK3 (0.37) | EIF2AK3MAPK1CYP3A4RIPK1 | |
| SCHEMBL14655668 | 0.73 | EIF2AK3 (0.60) | EIF2AK3MAPK1S1PR1PIK3CDCYP3A4 | |
| SCHEMBL14655630 | 0.70 | EIF2AK3 (0.61) | EIF2AK3MAPK1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL869093 | 0.68 | EIF2AK3 (0.55) | EIF2AK3MAPK1S1PR1RIPK1 | |
| SCHEMBL13861216 | 0.66 | EIF2AK3 (0.61) | EIF2AK3MAPK1RIPK1 | |
| SCHEMBL869218 | 0.65 | EIF2AK3 (0.72) | EIF2AK3RIPK1 | |
| SCHEMBL869492 | 0.65 | EIF2AK3 (0.56) | EIF2AK3MAPK1RIPK1 | |
| SCHEMBL16156132 | 0.64 | EIF2AK3 (0.58) | EIF2AK3MAPK1PIK3CDCYP3A4PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885MAPK1 5/4885S1PR1 961/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885MAPK1 5/4885S1PR1 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.