Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 14/20 | 0.55 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869492 | 0.91 | EIF2AK3 (0.56) | EIF2AK3EIF2AK2MAPK1RIPK1 | |
| SCHEMBL14655668 | 0.90 | EIF2AK3 (0.60) | EIF2AK3MAPK1RIPK1S1PR1 | |
| SCHEMBL869218 | 0.84 | EIF2AK3 (0.72) | EIF2AK3EIF2AK2RIPK1 | |
| SCHEMBL869246 | 0.82 | EIF2AK3 (0.48) | EIF2AK3EIF2AK2RIPK1 | |
| SCHEMBL868752 | 0.80 | EIF2AK3 (0.42) | EIF2AK3EIF2AK2MAPK1RIPK1 | |
| SCHEMBL14655630 | 0.80 | EIF2AK3 (0.61) | EIF2AK3EIF2AK2MAPK1 | |
| SCHEMBL868773 | 0.76 | EIF2AK3 (0.69) | EIF2AK3EIF2AK2MAPK1RIPK1 | |
| SCHEMBL868645 | 0.76 | EIF2AK3 (0.74) | EIF2AK3EIF2AK2RIPK1 | |
| SCHEMBL867820 | 0.75 | BRD4 (0.39) | EIF2AK3MAPK1 | |
| SCHEMBL869571 | 0.75 | BRD4 (0.39) | EIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885EIF2AK2 174/4885MAPK1 5/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885EIF2AK2 174/4885MAPK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.