Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | HTR1D | P28221 | 4/20 | 0.64 |
| ▸ | HTR1B | P28222 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26826151 | 0.86 | MAPT (0.65) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL2539868 | 0.84 | MAPT (0.62) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL8229566 | 0.82 | MAPT (0.87) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL31660992 | 0.81 | GAA (0.67) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL2536283 | 0.81 | GAA (0.67) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL2534045 | 0.81 | MAPT (0.69) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL5148298 | 0.80 | MAPT (0.68) | HTR1DHTR1BMAPTMEN1KMT2A | |
| SCHEMBL10753865 | 0.79 | GAA (0.58) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL5148291 | 0.79 | MAPT (0.70) | HTR1AHTR1DHTR1BMAPTMEN1 | |
| SCHEMBL10756727 | 0.77 | GAA (0.56) | HTR1AHTR1DHTR1BMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770742-A | SEROTONIN RECEPTOR SELECTIVITY, MIGRAINES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-23 | — | — | US | disclosed |
| WO-1997043281-A1 | THIOPHENE- AND FURAN-TRYPTAMINE DERIVATIVES | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-11-20 | — | — | WO | disclosed |