Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762770 | 0.83 | MAPT (0.68) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7745470 | 0.81 | ALDH1A1 (0.66) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28219732 | 0.81 | MAPT (0.50) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL162875 | 0.80 | KAT2B (0.60) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14839882 | 0.80 | KAT2B (0.64) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9781715 | 0.80 | KAT2B (0.64) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6198859 | 0.80 | KAT2B (0.80) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29516821 | 0.80 | KAT2B (0.64) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8544433 | 0.79 | MAPT (0.55) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9276000 | 0.79 | MAPT (0.51) | KAT2BMAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119606-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |
| EP-2621888-B1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | NOXELL CORP (US) | 2018-09-12 | — | — | EP | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8618326-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2621888-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | The Procter and Gamble Company (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012050593-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTER & GAMBLE COMPANY (US) | 2012-04-19 | — | — | WO | disclosed |
| US-20120078016-A1 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120078016-A1 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine | TYR, BTD, BRD4 | KAT2B 1885/4885MAPT 4602/4885SMN1; SMN2 2159/4885 |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | TYR, BTD, BRD4 | KAT2B 1885/4885MAPT 4602/4885SMN1; SMN2 2159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.