Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.58 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | MGLL | Q99685 | 2/20 | 0.55 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.54 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29179785 | 0.87 | POLB (0.62) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL1040107 | 0.84 | POLB (0.59) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL27789206 | 0.83 | ROCK2 (0.62) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL30076850 | 0.82 | POLB (0.57) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL31307421 | 0.82 | POLB (0.57) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL15332108 | 0.82 | POLB (0.57) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL16423708 | 0.82 | POLB (0.57) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL3795024 | 0.82 | POLB (0.68) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL10173263 | 0.81 | POLB (0.62) | POLBROCK2MAPTTP53KDM1A | |
| SCHEMBL14186812 | 0.81 | POLB (0.52) | POLBROCK2MAPTTP53KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773459-A | ENZYME INHIBITORS OF KINASES AND ANTICARCINOGENIC AGENTS | SUGEN, INC. (US) | 1998-06-30 | — | — | US | disclosed |
| WO-1996040673-A1 | NOVEL UREA- AND THIOUREA-TYPE COMPOUNDS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |