Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694090 | 1.00 | MEN1 (0.44) | MEN1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL5643255 | 0.85 | TDP1 (0.45) | MEN1KMT2ALMNANPSR1MAPT | |
| SCHEMBL8949906 | 0.84 | MAPT (0.47) | MEN1KMT2AMAPK1NPSR1MAPT | |
| SCHEMBL8949899 | 0.84 | MAPT (0.47) | MEN1KMT2AMAPK1NPSR1MAPT | |
| SCHEMBL1699439 | 0.83 | KMT2A (0.45) | MEN1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL1699438 | 0.83 | KMT2A (0.45) | MEN1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL17168992 | 0.82 | CYP19A1 (0.42) | KMT2ALMNANPSR1MAPTL3MBTL1 | |
| SCHEMBL1699673 | 0.79 | KMT2A (0.42) | MEN1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL1699672 | 0.79 | KMT2A (0.42) | MEN1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL1144241 | 0.78 | MAPT (0.46) | MEN1KMT2AMAPK1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843884-B | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as PDE1 inhibitors | H.隆德贝克有限公司 | 2022-03-04 | — | — | CN | disclosed |
| US-5712296-A | Substituted pyridines and 2-oxo-1,2-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1998-01-27 | — | — | US | disclosed |
| US-5492923-A | DRUG FOR TREATING ARTERIAL HYPERTENSION AND ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-20 | — | — | US | disclosed |
| EP-0623610-A1 | Substituted pyridines and 2-oxo-1,2-dihydropyridines as Angiotensine II antagonists | BAYER AG (DE) | 1994-11-09 | — | — | EP | disclosed |