Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL2036670 | 0.90 | KDM4E (0.45) | KDM4EALDH1A1TDP1PKMMAPT | |
| Methacrylic Acid SCHEMBL5066177 | 0.90 | KDM4E (0.45) | KDM4EALDH1A1TDP1PKMMAPT | |
| Acetoacetic Acid SCHEMBL8751811 | 0.88 | KDM4E (0.41) | KDM4EALDH1A1TDP1PKMMAPT | |
| Methyl Alcohol SCHEMBL4666816 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1TDP1PKMMAPT | |
| SCHEMBL1809220 | 0.88 | — | — | |
| SCHEMBL1809222 | 0.88 | — | — | |
| SCHEMBL9473130 | 0.88 | — | — | |
| SCHEMBL20721709 | 0.88 | — | — | |
| SCHEMBL16898634 | 0.88 | — | — | |
| SCHEMBL14857813 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470944-B2 | Polynorbornene pervaporation membrane films, preparation and use thereof | PROMERUS, LLC (US) | 2013-06-25 | — | — | US | claimed |
| US-20120283404-A1 | Polynorbornene Pervaporation Membrane Films, Preparation and Use Thereof | PROMERUS LLC (US) | 2012-11-08 | — | — | US | claimed |
| JP-4722828-B2 | — | — | 2011-07-13 | — | — | JP | claimed |
| EP-1597287-B1 | VINYL ADDITION POLYCYCLIC OLEFIN POLYMERS PREPARED WITH NON-OLEFINIC CHAIN TRANSFER AGENTS AND USES THEREOF | PROMERUS LLC (US) | 2010-05-05 | — | — | EP | claimed |
| US-7674847-B2 | Vinyl addition polycyclic olefin polymers prepared with non-olefinic chain transfer agents and uses thereof | PROMERUS LLC (US) | 2010-03-09 | — | — | US | claimed |
| EP-1597287-A4 | VINYL ADDITION POLYCYCLIC OLEFIN POLYMERS PREPARED WITH NON-OLEFINIC CHAIN TRANSFER AGENTS AND USES THEREOF | PROMERUS LLC (US) | 2008-12-17 | — | — | EP | claimed |
| US-20070066775-A1 | Vinyl addition polycylic olefin polymers prepared using non-olefinic chain transfer agents and uses thereof | PROMERUS LLC (US) | 2007-03-22 | — | — | US | claimed |
| EP-1597287-A2 | VINYL ADDITION POLYCYCLIC OLEFIN POLYMERS PREPARED WITH NON-OLEFINIC CHAIN TRANSFER AGENTS AND USES THEREOF | Promerus LLC (US) | 2005-11-23 | — | — | EP | claimed |
| US-20050192409-A1 | Polymers of polycyclic olefins having a polyhedral oligosilsesquioxane pendant group and uses thereof | PROMERUS, LLC | 2005-09-01 | — | — | US | claimed |
| US-20040229157-A1 | Vinyl addition polycyclic olefin polymers prepared with non-olefinic chain transfer agents and uses thereof | PROMERUS LLC | 2004-11-18 | — | — | US | claimed |
| WO-2004076495-A2 | VINYL ADDITION POLYCYCLIC OLEFIN POLYMERS PREPARED WITH NON-OLEFINIC CHAIN TRANSFER AGENTS AND USES THEREOF | PROMERUS LLC (US) | 2004-09-10 | — | — | WO | claimed |
| US-RE35717-E | NONPOLAR AND POLAR CYCLOOLEFINS, ACTIVATOR AND CATALYST, HIGH MODULUS AND IMPACT STRENGTH | METTON AMERICA, INC. (US) | 1998-01-20 | — | — | US | claimed |
| US-4689380-A | DICYCLOPENTADIENE-NORBORNENE ESTER, TUNGSTEN CATALYST, ALUMINUM ACTIVATOR | HERCULES INCORPORATED (US) | 1987-08-25 | — | — | US | claimed |
| US-9261781-B2 | Preparation of norbornane-based PAC ballasts | SUMITOMO BAKELITE CO., LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-8753790-B2 | Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom | PROMERUS, LLC (US) | 2014-06-17 | — | — | US | disclosed |
| US-8748074-B2 | Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom | PROMERUS, LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-4598102-A | DIALKYULAUMINUM OIDIDE ACTIVATOR | HERCULES INCORPORATED (US) | 1986-07-01 | — | — | US | disclosed |
| EP-0181640-A1 | Copolymers of dicyclopentadiene | HERCULES INCORPORATED (US) | 1986-05-21 | — | — | EP | disclosed |
| US-4584425-A | DISTILLING CYCLOOLEFIN, THEN CONTACTING WITH ADSORBENT, POLYMERIZING WITH METATHESIS CATALYST | HERCULES INCORPORATED (US) | 1986-04-22 | — | — | US | disclosed |
| US-4568660-A | TUNGSTEN CHLORIDE CONTAINING COMPOUND AND PHENOL COMPOUND | HERCULES INCORPORATED (US) | 1986-02-04 | — | — | US | disclosed |