Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.60 |
| ▸ | TOP2A | P11388 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 5/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8693296 | 0.97 | TP53 (0.58) | TP53CACNA2D1TOP2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8693301 | 0.97 | TP53 (0.58) | TP53CACNA2D1TOP2AKDM4EALDH1A1 | |
| SCHEMBL8697731 | 0.86 | RAD52 (0.63) | TOP2AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20867956 | 0.82 | KDM4E (0.61) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8694650 | 0.81 | KDM4E (0.62) | TOP2AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4726253 | 0.79 | CACNA2D1 (0.91) | CACNA2D1TOP2AKDM4EALDH1A1POLB | |
| SCHEMBL24249663 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL2683722 | 0.78 | CACNA2D1 (0.89) | CACNA2D1TOP2AKDM4EALDH1A1POLB | |
| SCHEMBL1187744 | 0.77 | KDM4E (0.80) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL16009276 | 0.77 | CACNA2D1 (0.51) | TP53CACNA2D1TOP2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770734-A | N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-06-23 | — | — | US | disclosed |
| US-5149815-A | Anticholirergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| US-5093333-A | N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-03 | — | — | US | disclosed |