Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.91 |
| ▸ | POLB | P06746 | 4/20 | 0.73 |
| ▸ | RAD52 | P43351 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.73 |
| ▸ | BCHE | P06276 | 2/20 | 0.65 |
| ▸ | TOP2A | P11388 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2683722 | 0.98 | CACNA2D1 (0.89) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL8288058 | 0.95 | CACNA2D1 (1.00) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL8288053 | 0.85 | CACNA2D1 (0.79) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL4725486 | 0.84 | RAD52 (1.00) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL31087715 | 0.84 | RAD52 (1.00) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL4913303 | 0.84 | KDM4E (0.79) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| Hydrochloric Acid SCHEMBL30662069 | 0.82 | SLC2A1 (0.65) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL9748474 | 0.82 | POLB (0.70) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL5578493 | 0.82 | POLB (0.79) | CACNA2D1POLBRAD52RAB9ASLC2A1 | |
| SCHEMBL7869214 | 0.82 | POLB (0.79) | CACNA2D1POLBRAD52RAB9ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020169183-A1 | Acridines as stimulators for Fas-mediated apoptosis | TELIK, INC. | 2002-11-14 | — | — | US | claimed |
| WO-2002072096-A1 | ACRIDINES AS STIMULATORS FOR FAS-MEDIATED APOPTOSIS | TELIK, INC. (US) | 2002-09-19 | — | — | WO | claimed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| WO-2008010984-A9 | ACRIDINE ACTIVATION OF P53 AND USES THEREOF | UNIV PENNSYLVANIA (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008010984-A2 | ACRIDINE ACTIVATION OF P53 AND USES THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20020169183-A1 | Acridines as stimulators for Fas-mediated apoptosis | TELIK, INC. | 2002-11-14 | — | — | US | disclosed |
| WO-2002072096-A1 | ACRIDINES AS STIMULATORS FOR FAS-MEDIATED APOPTOSIS | TELIK, INC. (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | KEAP1, TXNRD1, NFE2L2 | CACNA2D1 4762/4885POLB 3935/4885RAD52 2325/4885 |
| US-20020169183-A1 | Acridines as stimulators for Fas-mediated apoptosis | BAD, BAX, CASP3 | CACNA2D1 1494/4885POLB 3529/4885RAD52 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.