Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062433 | 0.90 | ALB (0.48) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL29400507 | 0.90 | ALB (0.48) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL9359175 | 0.90 | ALB (0.48) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL29383643 | 0.85 | MDM4 (0.51) | MDM4TP53MDM2CASP3 | |
| SCHEMBL29908041 | 0.85 | MDM4 (0.51) | MDM4TP53MDM2CASP3 | |
| SCHEMBL29929404 | 0.85 | MDM4 (0.51) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL12491518 | 0.85 | MDM4 (0.51) | MDM4TP53SLC17A5MDM2CASP3 | |
| SCHEMBL2306646 | 0.85 | MDM4 (0.51) | MDM4TP53MDM2CASP3 | |
| SCHEMBL800312 | 0.85 | MDM4 (0.51) | MDM4TP53MDM2CASP3 | |
| SCHEMBL799728 | 0.85 | MDM4 (0.51) | MDM4TP53SLC17A5MDM2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710129-A | Inhibitors of SH2-mediated processes | ARIAD PHARMACEUTICALS, INC. (US) | 1998-01-20 | — | — | US | claimed |
| WO-1997031016-A2 | NEW INHIBITORS OF SH2-MEDIATED PROCESSES | ARIAD PHARMACEUTICALS, INC. (US) | 1997-08-28 | — | — | WO | claimed |
| US-5710129-A | Inhibitors of SH2-mediated processes | ARIAD PHARMACEUTICALS, INC. (US) | 1998-01-20 | — | — | US | disclosed |
| WO-1997031016-A2 | NEW INHIBITORS OF SH2-MEDIATED PROCESSES | ARIAD PHARMACEUTICALS, INC. (US) | 1997-08-28 | — | — | WO | disclosed |