Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.81 |
| ▸ | DRD3 | P35462 | 2/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.81 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.81 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.81 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.81 |
| ▸ | DRD1 | P21728 | 1/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.81 |
| ▸ | HRH2 | P25021 | 1/20 | 0.81 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.81 |
| ▸ | HTR2A | P28223 | 1/20 | 0.81 |
| ▸ | HTR2C | P28335 | 1/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.81 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.81 |
| ▸ | HRH1 | P35367 | 1/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benztropine SCHEMBL8659140 | 0.90 | DRD2 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Benztropine SCHEMBL35388 | 0.90 | DRD2 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Benztropine SCHEMBL5960155 | 0.90 | DRD2 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Benztropine SCHEMBL35390 | 0.90 | DRD2 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Benztropine SCHEMBL35389 | 0.90 | DRD2 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Benztropine SCHEMBL4152475 | 0.88 | DRD2 (0.97) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL8697606 | 0.84 | DRD2 (0.83) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL2615299 | 0.84 | CHRM1 (0.89) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Clobenztropine SCHEMBL1152891 | 0.84 | DRD3 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| Clobenztropine SCHEMBL137213 | 0.84 | DRD3 (1.00) | DRD2DRD3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792775-A | HIGH AFFINITY FOR DOPAMINE TRANSPORTER; INHIBIT DOPAMINE UPTAKE; DO NOT HAVE A COCAINE-LIKE BEHAVORIAL PROFILE; USED TO IMAGE BINDING SITES; DIAGNOSIS AND MONITORING OF NEURODEGENERATIVE DISEASES, E.G PARKINSON'S | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-08-11 | — | — | US | disclosed |