Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.34 |
| ▸ | DRD4 | P21917 | 5/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8699448 | 0.81 | TACR1 (0.39) | TACR1DRD4SIGMAR1DRD3PDGFRA | |
| SCHEMBL8697361 | 0.79 | TACR1 (0.33) | TACR1DRD4SIGMAR1DRD3DRD2 | |
| SCHEMBL8701482 | 0.79 | TACR1 (0.34) | TACR1DRD4SIGMAR1DRD3TACR2 | |
| Hydrochloric Acid SCHEMBL8697913 | 0.77 | TACR1 (0.38) | TACR1DRD4SIGMAR1DRD3 | |
| SCHEMBL8697758 | 0.68 | TACR1 (0.56) | TACR1 | |
| SCHEMBL8887838 | 0.68 | TACR1 (0.56) | TACR1 | |
| SCHEMBL8458696 | 0.62 | TACR1 (0.47) | TACR1 | |
| SCHEMBL8161650 | 0.62 | TACR1 (0.47) | TACR1 | |
| SCHEMBL8702818 | 0.61 | TACR1 (0.45) | TACR1 | |
| SCHEMBL8701484 | 0.61 | TACR1 (0.56) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5830892-A | Piperidine and morphonline derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-11-03 | — | — | US | disclosed |