Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702818 | 0.81 | TACR1 (0.45) | TACR1FFAR4NR1H2RXRANR1H3 | |
| SCHEMBL8697754 | 0.81 | TACR1 (0.34) | TACR1PDGFRAS1PR1S1PR5DRD4 | |
| SCHEMBL8698438 | 0.79 | TACR1 (0.36) | TACR1KLK7 | |
| SCHEMBL8697769 | 0.78 | TACR1 (0.40) | TACR1FFAR4NR1H2RXRANR1H3 | |
| Hydrochloric Acid SCHEMBL8697913 | 0.77 | TACR1 (0.38) | TACR1FFAR4DRD4DRD3SIGMAR1 | |
| SCHEMBL8697361 | 0.75 | TACR1 (0.33) | TACR1DRD4DRD3SIGMAR1 | |
| SCHEMBL8699450 | 0.68 | TACR1 (0.60) | TACR1 | |
| SCHEMBL8889248 | 0.68 | TACR1 (0.60) | TACR1 | |
| SCHEMBL10132519 | 0.67 | HRH3 (0.52) | TACR1NR1H2NR1H3CETP | |
| SCHEMBL7916859 | 0.66 | TACR1 (0.40) | TACR1KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5830892-A | Piperidine and morphonline derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-11-03 | — | — | US | disclosed |