Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.62 |
| ▸ | THRA | P10827 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221473 | 0.86 | TDP1 (0.66) | THRATHRBSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL2473808 | 0.85 | L3MBTL1 (0.60) | SMN1; SMN2TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL12255182 | 0.85 | SMPD1 (0.64) | THRATHRBSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL11808372 | 0.84 | ESR1 (0.65) | ESR1THRATHRBALDH1A1KDM4E | |
| SCHEMBL931897 | 0.84 | KMT2A (0.69) | SMN1; SMN2TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL15766601 | 0.83 | SMPD1 (0.67) | THRATHRBSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8945545 | 0.83 | L3MBTL1 (0.59) | SMN1; SMN2TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL22438949 | 0.83 | SMPD1 (0.67) | THRATHRBSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL15766529 | 0.83 | SMPD1 (0.67) | THRATHRBSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL2930796 | 0.83 | TDP1 (0.59) | ALDH1A1SMN1; SMN2TDP1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998047877-A1 | 2-BENZOYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HEPATIC PRODUCTION OF APOB-100 | GLAXO GROUP LIMITED (GB) | 1998-10-29 | — | — | WO | disclosed |