Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.64 |
| ▸ | ATIC | P31939 | 3/20 | 0.51 |
| ▸ | DHFR | P00374 | 3/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lometrexol SCHEMBL12022771 | 0.92 | GART (0.75) | GARTATICDHFRTYMS | |
| Lometrexol SCHEMBL9045915 | 0.92 | GART (0.75) | GARTATICDHFRTYMS | |
| SCHEMBL7488545 | 0.89 | GART (0.71) | GARTATICDHFRTYMS | |
| SCHEMBL7487513 | 0.89 | GART (0.71) | GARTATICDHFRTYMS | |
| SCHEMBL9048275 | 0.87 | GART (0.69) | GARTATICDHFR | |
| SCHEMBL9536776 | 0.86 | GART (0.67) | GARTATICDHFRTYMS | |
| SCHEMBL7488700 | 0.85 | GART (0.66) | GARTATICDHFRTYMS | |
| SCHEMBL9844755 | 0.85 | GART (0.57) | GARTATICDHFRTYMS | |
| SCHEMBL9263123 | 0.85 | GART (0.63) | GARTATICDHFRTYMS | |
| SCHEMBL9844741 | 0.85 | GART (0.60) | GARTATICDHFRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998000426-A1 | 5,6,7,8-TETRAHYDROPYRIMIDO[4,5-b]AZEPINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1998-01-08 | — | — | WO | disclosed |