Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8698401 | 1.00 | GPR52 (0.51) | GPR52PTGER4PTGER3PTGER2SLC22A12 | |
| SCHEMBL10451654 | 0.86 | PTGER4 (0.56) | PTGER4PTGER3PTGER2SLC22A12ALDH1A1 | |
| SCHEMBL1006202 | 0.79 | AKR1B1 (0.53) | GPR52PTGER4PTGER3PTGER2SLC22A12 | |
| SCHEMBL28743677 | 0.79 | AKR1B1 (0.53) | GPR52PTGER4PTGER3PTGER2SLC22A12 | |
| SCHEMBL6361489 | 0.78 | FOLH1 (0.50) | PTGER4PTGER3PTGER2ALDH1A1LMNA | |
| SCHEMBL27717001 | 0.78 | PTGER3 (0.49) | PTGER4PTGER3PTGER2TAAR1PTGER1 | |
| SCHEMBL10689125 | 0.78 | PTGER3 (0.49) | PTGER4PTGER3PTGER2SLC22A12ALDH1A1 | |
| SCHEMBL27623546 | 0.78 | PTGER4 (0.49) | PTGER4PTGER3PTGER2SLC22A12ALDH1A1 | |
| SCHEMBL27580527 | 0.78 | PTGER4 (0.49) | GPR52PTGER4PTGER3PTGER2TAAR1 | |
| SCHEMBL24242098 | 0.77 | GPR52 (0.44) | GPR52PTGER4PTGER3PTGER2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101090886-B | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acids | DSM IP ASSETS BV | 2011-05-18 | — | — | CN | disclosed |
| CN-101090886-A | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acids | DSM IP ASSETS BV (NL) | 2007-12-19 | — | — | CN | disclosed |
| US-5827868-A | Prostaglandin analogs | E. R. SQUIBB & SONS, INC. (US) | 1998-10-27 | — | — | US | disclosed |
| EP-0536713-A1 | Oxazole and imidazole derivatives as prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1993-04-14 | — | — | EP | disclosed |