Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | ELOC | Q15369 | 1/20 | 0.42 |
| ▸ | ELOB | Q15370 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702160 | 0.87 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL11375358 | 0.83 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| Bromide SCHEMBL11377758 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8700995 | 0.80 | TSHR (0.42) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL7802849 | 0.79 | ALDH1A1 (0.56) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8429953 | 0.79 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8830212 | 0.79 | CYP3A4 (0.54) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL29079482 | 0.78 | NR4A1 (0.60) | PDE4APDE4BPDE4CPDE4DNR4A1 | |
| SCHEMBL11382721 | 0.77 | CYP1A2 (0.49) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL10899860 | 0.77 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0703913-B1 | IMIDAZOLES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0703913-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029299-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |