Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20513069 | 0.98 | ALDH1A1 (0.51) | ALDH1A1TDP1SMN1; SMN2MAPTHRH3 | |
| SCHEMBL22422294 | 0.81 | HRH3 (0.34) | ALDH1A1TDP1SMN1; SMN2MAPTHRH3 | |
| SCHEMBL3115863 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2HRH3HDAC6L3MBTL1HIF1A | |
| SCHEMBL29447400 | 0.74 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HRH3KDM4EL3MBTL1 | |
| SCHEMBL15707011 | 0.71 | SCD (0.44) | SMN1; SMN2HDAC6 | |
| SCHEMBL15889359 | 0.71 | — | — | |
| SCHEMBL7707975 | 0.71 | — | — | |
| SCHEMBL13711958 | 0.70 | ALDH1A1 (1.00) | ALDH1A1TDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL15896512 | 0.70 | ALDH1A1 (0.42) | ALDH1A1TDP1MAPTKDM4EKCNJ1 | |
| SCHEMBL12515889 | 0.70 | ALDH1A1 (1.00) | ALDH1A1TDP1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834460-A | FOR TREATMENT OF BRAIN OR PSYCHOLOGICAL DISORDERS, ALZHEIMER*S DISEASE, MENTAL RETARDATION OR AUTISM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0696586-A1 | SERINE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |