Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9390231 | 0.83 | ALDH1A1 (0.56) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL27466229 | 0.75 | ALDH1A1 (0.54) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL999516 | 0.75 | ALDH1A1 (0.56) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL21044135 | 0.74 | ALDH1A1 (0.52) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL11972348 | 0.74 | ALDH1A1 (0.55) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL9481200 | 0.74 | ALDH1A1 (0.55) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL8892561 | 0.73 | ALDH1A1 (0.51) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| Hydrochloric Acid SCHEMBL5250136 | 0.72 | ALDH1A1 (0.57) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL1000504 | 0.72 | ALDH1A1 (0.54) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL999180 | 0.72 | ALDH1A1 (0.54) | MAPTRAB9AALDH1A1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712270-A | TREATING PARKINSON*S DISEASE, DOWN*S SYNDROME, AND ALZHEIMER*S DISEASE WITH COGNITION ACTIVATORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-27 | — | — | US | disclosed |
| US-5510478-A | TREATMENT OF NEUROLOGICAL ILLNESSES RELATED TO CHOLINERGIC DEFICIENCY; ALZHEIMERS'S DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-23 | — | — | US | disclosed |