Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697780 | 0.90 | CYP19A1 (0.40) | CYP19A1CYP17A1KMT2AMAPTMEN1 | |
| SCHEMBL8696966 | 0.86 | MAPT (0.40) | CYP19A1CYP17A1KMT2AMAPTMEN1 | |
| SCHEMBL8702846 | 0.86 | CYP19A1 (0.57) | CYP19A1CYP17A1KMT2AMAPTMEN1 | |
| SCHEMBL8697621 | 0.84 | CYP19A1 (0.61) | CYP19A1CYP17A1KMT2AMAPTMEN1 | |
| SCHEMBL8697636 | 0.83 | CYP19A1 (0.45) | CYP19A1MAPTHPGDCYP3A4CYP11B1 | |
| SCHEMBL8702874 | 0.82 | IDO1 (0.35) | CYP19A1KMT2AMEN1ALDH1A1IDO1 | |
| SCHEMBL8700795 | 0.79 | CYP19A1 (0.60) | CYP19A1CYP3A4PDE4BCYP11B1CYP11B2 | |
| SCHEMBL8702824 | 0.73 | CYP17A1 (0.64) | CYP19A1CYP17A1KMT2AMAPTMEN1 | |
| SCHEMBL8698220 | 0.72 | CYP19A1 (0.69) | CYP19A1CYP3A4MAPK1NPC1 | |
| SCHEMBL8697823 | 0.72 | CYP19A1 (0.60) | CYP19A1CYP17A1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |