Bromide

Bromide

SCHEMBL8699689

[Br-].c1ccc([P+](CCCc2cccs2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.48
HIF1A Q16665 1/20 0.47
TSHR P16473 3/20 0.42
CYP2C19 P33261 2/20 0.42
ALDH1A1 P00352 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
NPC1 O15118 1/20 0.38
SLC6A3 Q01959 1/20 0.38
ADRA2A P08913 2/20 0.38
ADRA2B P18089 2/20 0.38
ADRA2C P18825 2/20 0.38
HTT P42858 1/20 0.37
POLB P06746 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL4750734 0.78 CYP2C19 (0.48) TAAR1HIF1ATSHRCYP2C19ALDH1A1
SCHEMBL20135772 0.74 TAAR1 (0.73) TAAR1TSHRCYP2C19ALDH1A1NPC1
Bromide SCHEMBL2446042 0.74 HIF1A (0.74) HIF1ATSHRCYP2C19ALDH1A1CYP1A2
SCHEMBL20146704 0.74 TAAR1 (0.73) TAAR1TSHRCYP2C19ALDH1A1NPC1
Bromide SCHEMBL2449969 0.74 HIF1A (0.74) HIF1ATSHRCYP2C19ALDH1A1CYP1A2
Hydrochloric Acid SCHEMBL1680771 0.74 CYP2C19 (0.48) TAAR1HIF1ATSHRCYP2C19ALDH1A1
SCHEMBL30963576 0.74 TAAR1 (0.55) TAAR1TSHRCYP2C19ALDH1A1NPC1
Iodide SCHEMBL3976020 0.74 CYP2C19 (0.48) TAAR1HIF1ATSHRCYP2C19ALDH1A1
SCHEMBL4729485 0.74 TAAR1 (0.55) TAAR1TSHRCYP2C19ALDH1A1ADRA2A
SCHEMBL27346489 0.74 CYP2C19 (0.62) TAAR1TSHRCYP2C19ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998005651-A1 NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYL QUINOXALINEDIONES WARNER-LAMBERT COMPANY (US) 1998-02-12 WO disclosed