Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4750734 | 0.96 | CYP2C19 (0.48) | CYP2C19SNCAHIF1ASLC6A3HTT | |
| Iodide SCHEMBL3976020 | 0.96 | CYP2C19 (0.48) | CYP2C19SNCAHIF1ASLC6A3HTT | |
| Bromide SCHEMBL10385733 | 0.79 | CYP2C19 (0.41) | CYP2C19SNCAHIF1ASLC6A3HTT | |
| Bromide SCHEMBL8699689 | 0.74 | TAAR1 (0.48) | CYP2C19HIF1ASLC6A3HTTTAAR1 | |
| Bromide SCHEMBL10385734 | 0.69 | CYP2C19 (0.46) | CYP2C19SLC6A3HTTTAAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5233539 | 0.69 | SLC6A3 (0.47) | SNCAHIF1ASLC6A3CYP2D6PKM | |
| Bromide SCHEMBL7630241 | 0.69 | HIF1A (0.40) | CYP2C19SNCAHIF1AALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9292231 | 0.69 | HIF1A (0.55) | CYP2C19SNCAHIF1ASLC6A3TAAR1 | |
| Hydrochloric Acid SCHEMBL2446696 | 0.69 | SNCA (0.69) | CYP2C19SNCAHIF1ASLC6A3TAAR1 | |
| Hydrochloric Acid SCHEMBL494 | 0.69 | SNCA (0.63) | CYP2C19SNCAHIF1ASLC6A3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3480224-B1 | ELECTRO-OPTIC POLYMER | NAT INST INF & COMM TECH (JP) | 2024-06-12 | — | — | EP | disclosed |
| US-11236188-B2 | Electro-optic polymer | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2022-02-01 | — | — | US | disclosed |
| EP-3761106-A1 | POLYCARBONATE HAVING ELECTRO-OPTIC EFFECT, METHOD FOR PRODUCING SAME, AND LIGHT CONTROL ELEMENT WHICH USES SAID POLYCARBONATE | Teijin Limited (JP) | 2021-01-06 | — | — | EP | disclosed |
| US-20200407498-A1 | POLYCARBONATE HAVING ELECTRO-OPTIC EFFECT, METHOD FOR PRODUCING SAME, AND LIGHT CONTROL ELEMENT WHICH USES SAID POLYCARBONATE | TEIJIN LIMITED (JP) | 2020-12-31 | — | — | US | disclosed |
| US-10754064-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2020-08-25 | — | — | US | disclosed |
| US-20190225728-A1 | ELECTRO-OPTIC POLYMER | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2019-07-25 | — | — | US | disclosed |
| EP-3480224-A1 | ELECTRO-OPTIC POLYMER | National Institute of Information and Communications Technology (JP) | 2019-05-08 | — | — | EP | disclosed |
| US-20180224577-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2018-08-09 | — | — | US | disclosed |
| US-9977150-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2018-05-22 | — | — | US | disclosed |
| US-9488755-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2016-11-08 | — | — | US | disclosed |
| EP-0904272-B1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIV VANDERBILT (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-1254904-A1 | NOVEL PIPERIDINE COMPOUNDS AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-11-06 | — | — | EP | disclosed |
| CN-1072668-C | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | VANDEBERT UNIV (US) | 2001-10-10 | — | — | CN | disclosed |
| US-6013656-A | PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; NERVOUSSYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0904272-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| CN-1210534-A | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | PROCTER & GAMBLE (US) | 1999-03-10 | — | — | CN | disclosed |
| US-5849760-A | 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5686471-A | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1997028155-A1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1997-08-07 | — | — | WO | disclosed |
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225728-A1 | ELECTRO-OPTIC POLYMER | UACA, ELAVL1, EYA3 | SLC6A3 2636/4885CYP2C19 4471/4885SNCA 3255/4885 |
| US-11236188-B2 | Electro-optic polymer | UACA, ELAVL1, EYA3 | SLC6A3 2636/4885CYP2C19 4471/4885SNCA 3255/4885 |
| US-10754064-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | OGFOD1, OCIAD2, OCIAD1 | SLC6A3 2757/4885CYP2C19 945/4885SNCA 612/4885 |
| US-20180224577-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | OGFOD1, OCIAD2, OCIAD1 | SLC6A3 2757/4885CYP2C19 945/4885SNCA 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.