Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 9/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9723539 | 0.88 | KCNH2 (0.56) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL9723418 | 0.88 | KCNH2 (0.56) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL8698523 | 0.87 | KCNH2 (0.52) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL17627703 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL1866120 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL11745664 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL17627701 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL4933865 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL132597 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT | |
| SCHEMBL9723550 | 0.85 | KCNH2 (0.55) | KCNH2TDP1TSHRKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731320-A | TREATING PATIENT IN NEED OF IMMUNOSUPPRESSIVE, ANTIINFLAMMATORY OR ANTIPROLIFERATIVE THERAPY | ABBOTT LABORATORIES (US) | 1998-03-24 | — | — | US | disclosed |
| US-5672605-A | ADMINISTERING TO TREAT AUTOIMMUNE DISORDERS, TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 1997-09-30 | — | — | US | disclosed |
| US-5643918-A | MACROCYCLIC COMPOUNDS TO REVERSE DRUG RESISTANCE, VIRICIDES, ANTIINFLAMMATORY AGENTS AND FUNGICIDES | ABBOTT LABORATORIES (US) | 1997-07-01 | — | — | US | disclosed |
| US-5583139-A | Marcolide immunomodulators | ABBOTT LABORATORIES (US) | 1996-12-10 | — | — | US | disclosed |
| US-5563172-A | MICROBIOCIDES, FUNGICIDES, VIRICIDES, ANTIINFLAMMATORY AGENTS, ANTIGROWTH AGENTS | ABBOTT LABORATORIES (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0729471-A1 | SEMISYNTHETIC ANALOGS OF RAPAMYCIN (MACROLIDES) BEING IMMUNOMODULATORS | Abbott Laboratories (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5527907-A | IMMUNOSUPPRESSANTS | ABBOTT LABORATORIES (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0689545-A4 | MACROCYCLIC AMIDE AND UREA IMMUNOMODULATORS | ABBOTT LAB (US) | 1996-04-24 | — | — | EP | disclosed |
| EP-0689545-A1 | MACROCYCLIC AMIDE AND UREA IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1996-01-03 | — | — | EP | disclosed |
| WO-1995014023-A1 | SEMISYNTHETIC ANALOGS OF RAPAMYCIN (MACROLIDES) BEING IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1994021642-A1 | MACROCYCLIC AMIDE AND UREA IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1994-09-29 | — | — | WO | disclosed |