Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700505 | 1.00 | IDH1 (0.39) | IDH1CASP3CASP7CASP8 | |
| SCHEMBL6074316 | 1.00 | IDH1 (0.39) | IDH1CASP3CASP7CASP8 | |
| SCHEMBL8879648 | 0.76 | IDH1 (0.32) | IDH1 | |
| SCHEMBL8881208 | 0.71 | — | — | |
| SCHEMBL5630073 | 0.67 | IDH1 (0.40) | IDH1 | |
| SCHEMBL24924007 | 0.67 | IDH1 (0.36) | IDH1 | |
| Methane SCHEMBL9384299 | 0.66 | IDH1 (0.42) | IDH1 | |
| SCHEMBL13564628 | 0.65 | IDH1 (0.36) | IDH1 | |
| SCHEMBL6137289 | 0.65 | IDH1 (0.36) | IDH1 | |
| SCHEMBL21212576 | 0.63 | IDH1 (0.35) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767133-A | Secondary amines as antidiabetic and antiobesity agents | PFIZER INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0703911-B1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| US-5627200-A | β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia | PFIZER INC (US) | 1997-05-06 | — | — | US | disclosed |
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5576442-A | Process and chiral intermediates for thiazole antidiabetics | PFIZER INC. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5576442-A | Process and chiral intermediates for thiazole antidiabetics | PFIZER INC. (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0708764-A1 | ENANTHIOSELECTIVE PREPARATION OF THIAZOLE DERIVATIVES | PFIZER INC. (US) | 1996-05-01 | — | — | EP | disclosed |
| EP-0703911-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| EP-0641331-A1 | CHIRAL INTERMEDIATES FOR THE PREPARATION OF ANTIDIABETICS THIAZOLES | PFIZER INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0641331-A1 | CHIRAL INTERMEDIATES FOR THE PREPARATION OF ANTIDIABETICS THIAZOLES | PFIZER INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1995002585-A1 | ENANTHIOSELECTIVE PREPARATION OF THIAZOLE DERIVATIVES | PFIZER INC. (US) | 1995-01-26 | — | — | WO | disclosed |
| WO-1994029290-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| WO-1993002061-A1 | CHIRAL INTERMEDIATES FOR THE PREPARATION OF ANTIDIABETICS THIAZOLES | PFIZER, INC. (US) | 1993-02-04 | — | — | WO | disclosed |
| WO-1993002061-A1 | CHIRAL INTERMEDIATES FOR THE PREPARATION OF ANTIDIABETICS THIAZOLES | PFIZER, INC. (US) | 1993-02-04 | — | — | WO | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |