Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9671906 | 0.91 | AGTR1 (0.47) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL8705729 | 0.86 | AGTR1 (0.38) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9671900 | 0.85 | AGTR1 (0.54) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9673669 | 0.85 | AGTR1 (0.56) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| Hydrochloric Acid SCHEMBL9674145 | 0.84 | AGTR1 (0.54) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| Hydrochloric Acid SCHEMBL9671929 | 0.84 | AGTR1 (0.56) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9672287 | 0.82 | AGTR1 (0.72) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9672035 | 0.82 | AGTR1 (0.48) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL6502825 | 0.82 | AGTR1 (0.48) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL8702000 | 0.82 | AGTR1 (0.47) | AGTR1LTB4R2AGTR2ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | claimed |
| EP-0475898-A1 | Azacyclic compounds | CIBA-GEIGY AG (CH) | 1992-03-18 | — | — | EP | claimed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |
| EP-0475898-A1 | Azacyclic compounds | CIBA-GEIGY AG (CH) | 1992-03-18 | — | — | EP | disclosed |