Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 15/20 | 0.49 |
| ▸ | HTR1B | P28222 | 15/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660431 | 0.84 | HTR1D (0.70) | HTR1DHTR1B | |
| SCHEMBL8659434 | 0.83 | HTR1D (0.49) | HTR1DHTR1BHTR1AHTR2AHTR5A | |
| SCHEMBL7474856 | 0.83 | HTR1D (0.68) | HTR1DHTR1BHTR1AHTR2AHTR5A | |
| SCHEMBL8662428 | 0.81 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL8701597 | 0.80 | HTR1D (0.47) | HTR1DHTR1BHTR1AHTR2AHTR5A | |
| SCHEMBL8664204 | 0.77 | HTR1D (0.59) | HTR1DHTR1B | |
| SCHEMBL8661505 | 0.76 | HTR1D (0.71) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8661705 | 0.74 | HTR1D (0.54) | HTR1DHTR1B | |
| SCHEMBL8659203 | 0.72 | HTR1D (0.45) | HTR1DHTR1BHTR5A | |
| SCHEMBL8664620 | 0.71 | HTR1D (0.61) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| US-5854247-A | Piperazine, piperidine and tetrahydropyridine derivatives useful as 5-HT1 recepter agonists | MERCK SHARP & DOHME LTD. (GB) | 1998-12-29 | — | — | US | disclosed |